产品货号：
Z12238
中文名称：
Calpain 1/CAPN1抗体
英文名称：
Anti-Calpain 1/CAPN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Calpain 1/CAPN1 Antibody |
| 指标别名 | Calpain 1;Calpain 1 catalytic subunit;Calpain 1 large subunit;Calpain mu type;CANP;CANP 1;CANP1;CANPL1;CAPN1;Micromolar calpain;muCANP;muCL |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF |
| 基因名称 | CAPN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human Calpain 1(312-326aa EWNNVDPYERDQLRV),different from the mouse sequence by two amino acids. |
| 实际分子量 | 82KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene.Calpain is an intracellular protease that requires calcium for its catalytic activity.Two isozymes,calpain I(mu-calpain) and calpain II(m-calpain),with different calcium requirements,have been identified.Both are heterodimers composed of L(large,catalytic,80kD) and S(small,regulatory,30kD) subunits.The isozymes share an identical S subunit,with the differences arising from the L subunits,L1(CAPN1) and L2.By quantitative RT-PCR,Ueyama et al.(1998) found that expression of calpain-1 and calpain-2 mRNA was significantly increased in muscle biopsy samples derived from 5 men with progressive muscular dystrophy(e.g.,DMD;310200) and 2 men and 3 women with amyotrophic lateral sclerosis(ALS;105400) compared with controls.Using cDNA clones as probes,Ohno et al.(1989,1990) assign CANPL1 to chromosome 11. |
| Uniprot ID | P07384 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | calpain 1,(mu/I) large subunit |
| 蛋白名全称 | Calpain-1 catalytic subunit |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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